About Phentermine Juno ER

Traditional extended release formulations of phentermine contain indigestible sodium polystyrene sulphonate beads1,2, Phentermine Juno ER tablets are a patented soluble extended release formulation consisting of a hydrophobic-hydrophilic matrix3.

Phentermine Juno ER’s extended release formulation, differs from Duromine® by delivering phentermine free from2:

  • Indigestible sodium polystyrene sulphonate beads (microplastics)
  • Lactose
  • Gelatin
  • Animal products
  • Reliance on gut ionic strength and pH

Phentermine Juno ER tablets are coated and shaped as a capsule for improved patient acceptability4

Development of
Phentermine Juno ER

Juno PC Holdings Pty Ltd (An Australian based and majority owned Company) are developers and license holders of a new phentermine extended release tablet, bioequivalent to Duromine®.1

The result of a successful Australian and Swiss collaboration, Phentermine Juno ER is the first microplastics free phentermine to be made available in Australia.2,5,6

Delivering the well-known appetite suppressant benefits of phentermine for weight loss, Phentermine Juno ER features a patented extended release technology which is free from lactose, gluten, gelatin or animal products, which may lower the potential for intolerance or allergic reactions.7-11

While the use of an Ion Exchange Resin has been an important mechanism for delivering phentermine in traditional formulations, this can now be delivered with Phentermine Juno ER’s newer alternative matrix formulation.1,2

Next generation Phentermine Juno ER – how is it different?

By removing reliance on sodium polystyrene sulphonate beads, Phentermine Juno ER utilises a next generation delivery system free from microplastics.1,2 This new formulation is free from lactose, gluten and gelatin, which may lower the potential for intolerance or allergic reactions.7-11

Comparing phentermine formulations:

The two phentermine formulations now available in Australia are:

  • Traditional formulations of phentermine – which are Ion Exchange Resin capsule formulations and
  • New Phentermine Juno ER tablets– which are an Extended Release Matrix formulations.

These 2 formulations take a very different pathway to delivering phentermine – but which result in bioequivalent plasma profiles.3

Traditional FormulationsPhentermine Juno ER
Traditional FormulationsPhentermine Juno ER

Phentermine Juno ER1,3

Unlike traditional formulations, Phentermine Juno ER tablets have a mix of hydrophobic and hydrophilic components that form a solid matrix within which phentermine is embedded. Body temperature and fluids cause the tablet to slowly break down and release phentermine.

Ion Exchange Resin Formulations12-15

Traditional phentermine formulations use an Ionic Exchange Resin which is formed from polystyrene sulphonate (Polystyrene Resin), enclosed in a capsule. In manufacturing the phentermine attaches to the polystyrene resin due to ionic charge and then releases in the gastrointestinal tract (GIT) when exposed to ionic charge.

Phentermine Juno ER pharmacokinetics are similar to traditional formulations without the insoluble beads1-3.

*not to scale
** Brands include Duromine®, Metermine® and Phentermine GH
# The majority of ionic exchange resin formulations contain lactose. Phentermine GH (Lupin) is lactose free.

How does
Phentermine Juno ER compare?

By removing reliance on sodium polystyrene sulphonate beads, Phentermine Juno ER utilises a next generation delivery system free from microplastics.1,2 This new formulation is free from lactose, gluten and gelatin, which may lower the potential for intolerance or allergic reactions.7-11

How does
Phentermine Juno ER compare?

By removing reliance on sodium polystyrene sulphonate beads, Phentermine Juno ER utilises a next generation delivery system free from microplastics.1,2 This new formulation is free from lactose, gluten and gelatin, which may lower the potential for intolerance or allergic reactions.7-11

*not to scale
** Brands include Duromine®, Metermine® and Phentermine GH
# The majority of ionic exchange resin formulations contain lactose. Phentermine GH (Lupin) is lactose free.

Phentermine Juno ER is bioequivalent to Duromine

Bioequivalence has been established between Phentermine Juno ER tablets (phentermine as hydrochloride Extended Release) and Duromine® capsules (phentermine as an ion exchange resin complex) across all 3 tablet strengths, i.e. 15mg, 30mg and 40mg with fed, fast and steady state studies performed.1,3

Fed Bioequivalence study3

       Pharmacokinetics: Mean plasma profile phentermine 40mg tablet capsule study
       N=42 Healthy volunteers. Single fed dosing study

Why is Phentermine Juno ER environmentally friendly?

Phentermine Juno ER does not contain sodium polystyrene sulfonate. Sodium polystyrene sulfonates are polystyrene beads and a form of microplastic.5,12,16
When sodium polystyrene sulfonate is ingested, the polystyrene beads pass through the gastrointestinal system and into our waste water,12,15 where they unable to be removed from the environment.16-18 Microplastics are implicated in water contamination that affects the health of our waterways and eventually ends up in our food web. Microplastics are small enough to be incorporated into plants and animals16-19.

Phentermine Juno ER availability

and product information

Phentermine Juno ER was jointly developed by an Australian Company and its Swiss partner – quality manufactured in Switzerland.

Phentermine Juno ER is available from Sigma, API and Symbion Wholesalers in the following packs and dosages.

Phentermine Juno ER
Tablet 15mg x 30
Phentermine (as
hydrochloride)
Bioequivalent to
Duromine® capsule
15mg x 301

Extended Release
Tablet. Film coated in
shape of a capsule

Phentermine Juno ER
Tablet 30 mg x 30
Phentermine (as
hydrochloride)
Bioequivalent to
Duromine® capsule
30mg x 301

Extended Release
Tablet. Film coated in
shape of a capsule

Phentermine Juno ER
Tablet 40mg x 30
Phentermine (as
hydrochloride)
Bioequivalent to
Duromine® capsule
40mg x 301

Extended Release
Tablet. Film coated in
shape of a capsule

Phentermine Juno ER availability

and product information

Phentermine Juno ER was jointly developed by an Australian Company and its Swiss partner – quality manufactured in Switzerland.

Phentermine Juno ER is available from Sigma, API and Symbion Wholesalers in the following packs and dosages.

Phentermine Juno ER Tablet 15mg x 30 Phentermine (as hydrochloride)

Bioequivalent to Duromine® capsule 15mg x 301

Extended Release Tablet. Film coated in shape of a capsule

Phentermine Juno ER Tablet 30mg x 30 Phentermine (as hydrochloride)

Bioequivalent to Duromine® capsule 30mg x 301

Extended Release Tablet. Film coated in shape of a capsule

Phentermine Juno ER Tablet 40mg x 30 Phentermine (as hydrochloride)

Bioequivalent to Duromine® capsule 40mg x 301

Extended Release Tablet. Film coated in shape of a capsule

Product Resources

Juno PC are please to support the healthcare professionals with the following resources:

References1. PHENTERMINE JUNO ER Product Information. 2. PHENTERMINE JUNO ER ARTG Public Summary Document, 9/01/2020. 3. Data on file. 4. Overgaard A et al 2001. Patients’ evaluation of shape, size and colour of solid dosage forms. Pharm World Sci 23, 185-88 5. Duromine ARTG Public Summary Document, 11/10/2019. 6. PHENTERMINE GH ARTG Public Summary Document, 4/05/2020 7. Fassio et al 2018. Lactose Maldigestion, Malbsorption, and Intolerance. A Comprehensive Review with a Focus on Current Management and Future Perspectives. Nutrients 10, 15599 8. Land M et al 2013. Near fatal anaphylaxis from orally administered gelatin capsule. J Allergy Clin Immunol: In Practice. 1, 99-100 9. Pifferi G & Restani R 2003. The safety of pharmaceutical excipients. Il Farmaco 58, 541-50. 10. Strauss J & Greeff O. 2015. Excipient-related adverse drug reactions: A clinical approach. Current Allergy & Clinical Immunology 28, 24-27 11. Mullins R et al 2012. Relationship between red meat allergy and sensitisation to gelatin and galactose. J Allergy Clin Immunol 129, 1334-42. 12. Sivaneswari S et al 2015. Ion exchange resins as drug delivery carriers. J. Chem. Pharm Res. 7, 1436-1445. 13. Duromine Product Information. 14 September 2018. 14. Rohm and Hass Product overview 2006_Amberlite IRP69 (Sodium Polystyrene Sulfonate). 15. Emmett et al 2019. Clinical Pharmacology for Prescribing, Oxford University Press. UK. 16. Gausepohl H & Neibner N. 2001. Polystyrene and Styrene Copolymers in Encyclopedia of Materials: Science and Technology. Elsevier. UK. 17. Ballent A et al 2016. Sources and Sinks of Microplastics in Canadian Lake Ontario Nearshore, Tributary and Beach Sediments. In Earth Sciences Publications. Canada. 18. EPA NSW 2016. Plastic microbeads in products and the environment. Environment Protection Authority 2016. www.epa.nsw.gov.au 19. The microbead free waters Act FAQ, sourced from https://www.fda.gov/cosmetics/cosmetics-laws-regulations/microbead-free-waters-act-faqs

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If you have a Phentermine Juno ER question please contact us

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